Contatti: rebecca.moroni@phd.unipi.it ; rebe.moroni@gmail.com
Supervisore tesi: Prof. Francesco Camillo
Titolo Progetto: L’ozonoterapia per il trattamento dell’endometrite negli Equidi
Abstract: L’endometrite è un’infiammazione, con o senza un processo infettivo, a carico dello strato interno della mucosa uterina; la sua persistenza può rendere l’ambiente uterino sfavorevole al concepimento, riducendo così il potenziale riproduttivo della cavalla. Generalmente, viene trattata attraverso l’uso di lavande uterine, farmaci ecbolici e antinfiammatori, e antimicrobici, se e quando necessario. Tuttavia, la mancanza di risposta alla terapia tradizionale e la crescente incidenza di agenti patogeni resistenti agli antimicrobici hanno portato allo sviluppo di terapie alternative per il trattamento delle cavalle affette da endometrite cronica, tra cui si ricordano il plasma ricco di piastrine e l’ozonoterapia (O3). Il trattamento intrauterino a base di O3 si è dimostrato efficace nel ridurre l’infiammazione uterina nelle vacche e nella promozione locale dell’angiogenesi endometriale nelle cavalle. Inoltre, la terapia con O3 presenta un effetto antimicrobico, dimostrato sia in vitro che in vivo. Pertanto, dal momento che non sono ancora disponibili studi che vadano ad indicare un protocollo standardizzato da seguire per il trattamento con ozono dell’endometrite nelle cavalle, il nostro studio mirerà a valutare l’efficacia del trattamento intrauterino a base di una miscela di gas O2-O3 per curare tale patologia.
Project title: Ozonetherapy as a treatment for endometritis in Equidae
Abstract: Endometritis is an inflammation, with or without an infectious process, affecting the inner layer of the uterine mucosa; its persistence can make the uterine environment unfavorable to the conceptus, thus reducing the reproductive potential of the mare. Generally, it is treated through the use of uterine lavages, ecbolic and anti-inflammatory drugs, and antimicrobials, as and when needed. However, the lack of response to traditional therapy and the increasing incidence of antimicrobial-resistant pathogens have led to the development of alternative therapies for the treatment of mares with chronic endometritis, including platelet-rich plasma and ozone therapy (O3). Intrauterine treatment with O3 has been shown to be effective in reducing uterine inflammation in cows and in promoting local endometrial angiogenesis in mares. Furthermore, O3 therapy exhibits an antimicrobial effect, demonstrated both in vitro and in vivo. Therefore, since no studies are yet available that indicate a standardized protocol to be followed for the ozone treatment of endometritis in mares, our study will aim to evaluate the efficacy of intrauterine treatment based on a mixture of O2-O3 gas to treat this pathology.
SCOPUS: https://www.scopus.com/authid/detail.uri?authorId=57220046535
ORCID ID: https://orcid.org/0000-0002-2108-1749
Pubblicazioni:
- Panzani D, Quaresma M, Fanelli D, Camillo F, Moroni R, Rota A, Martins-Bessa A, Nóvoa M, Catalán J, Canisso IF, Conte G, Mirò J. Hastening Time to Ejaculation in Donkey Jacks Treated with the PGF2α Analog, Cloprostenol Sodium. Animals. 2020;10(12):2231. https://doi.org/10.3390/ani10122231
- Fanelli D, Moroni R, Bocci C, Camillo F, Rota A, Panzani D. Interspecific and Intraspecific Artificial Insemination in Domestic Equids. Animals. 2023;13(4):582. https://doi.org/10.3390/ani13040582
- Moroni R, Panzani D, Camillo F, Rota A, Fanelli D, Cantile C, Marmorini P, Salamone G, Ori M. Endometrial expression of antimicrobial peptides as markers of subclinical endometritis in mares. Equine veterinary journal. 2024; 56(4):670–677. https://doi.org/10.1111/evj.14080
- Martini M, Degl’Innocenti A, Altomonte I, Sodi I, Bocci C, Fanelli D, Moroni R, Panzani D, Camillo F, Salari F. Report on a Milking Mule: Milk Qualitative Characteristics during Lactation. Animals. 2024; 14(11):1585. https://doi.org/10.3390/ani14111585
Scopus link: https://www.scopus.com/authid/detail.uri?authorId=57220046535
ORCID ID: https://orcid.org/0000-0002-2108-1749
Comunicazioni orali a congresso:
- Moroni*, D. Fanelli, M. Tesi, B. Cerretini, D. Lomet, A. Rota, M. Beltramo, F. Camillo, D. Panzani. Effect of administration of the C6 kisspeptin analogue in jennies in estrous. 10th ISEET, Pisa, 2022.
- Moroni R*, Marmorini P, Fanelli D, Melanie P, Cantile C, Passamonti F, Camillo F, Rota A, Panzani D. The effects of uterine ozone insufflation in mares affected by endometritis: preliminary results. 76° convegno SISVET, Bari, 2023.
- Moroni R*, Ori M, Camillo F, Rota A, Fanelli D, Cantile C, Marmorini P, Salamone G, Panzani D. Endometrial expression of antimicrobial peptides as markers of subclinical endometritis in mares. 1st Game of Research, Pisa, 2023.
- Moroni R*, Maltinti S, Fanelli D, Camillo F, Rota A, Cantile C, Marmorini P, Orefice M, Ori M, Panzani D. Endometrial expression of antimicrobial peptides as markers of subclinical endometritis in mares. 2nd ECAR, Zurigo, 2024.
Poster a congresso:
- Bocci*, D. Fanelli, R. Moroni, M. Tesi, F. Camillo, S. Wilsher, W.R. Allen. Pregnancy rates in equids after interspecific and intraspecific artificial insemination. 10th ISEET, Pisa, 2022.
- Fanelli*, L. Losinno, C. Castañeira, C. Alonso, A. Flores Bragulat, D. Panzani, C. Bocci, A. Degl’Innocenti, R. Moroni, F. Camillo, S. Wilsher, W.R. Allen. First report of mule-in-mule pregnancies with live births following embryo transfer. 10th ISEET, Pisa, 2022.
- Moroni R*, Panzani D, Camillo F, Rota A, Fanelli D, Franco AM, Ori Endometrial gene expression of DEFB4B, LYZ, and SLPI in biopsy samples of mares resistant or susceptible to endometritis. 13° ISER, Brasile, 2023.
- Fanelli D*, Moroni R, Camillo F, Rota A, Panzani D. The GnRH analogue Decapeptyl was able to induce ovulation in cyclic jennies. 13° ISER, Brasile, 2023.
- Fanelli, L. Losinno, C. Castañeira, C. Alonso, A. Flores Bragulat, D. Panzani, C. Bocci, A. Degl’Innocenti, R. Moroni*, F. Camillo, S. Wilsher, W.R. Allen. First report of mule-in-mule pregnancies with live births following embryo transfer. 1st Game of Research, Pisa, 2023.